NR or NMN Supplement Guide: Benefits, Dosage & Reviews
To increase cellular NAD+ levels, potentially supporting healthy aging, cellular energy metabolism, and DNA repair processes
Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are precursors to NAD+ (nicotinamide adenine dinucleotide), a crucial coenzyme involved in cellular energy metabolism, DNA repair, and aging processes. Both compounds aim to boost declining NAD+ levels associated with aging.
NR or NMN Key Metrics & Safety Profile
Research Quality & Regulatory Status
FDA & Regulatory Status
NR (Niagen) received GRAS status for use in foods and beverages. NMN has not received FDA approval as a supplement and regulatory status remains unclear
Where to Buy NR or NMN
Compare prices from trusted brands.
💡 Pro Tip: Start with the lowest effective dose and monitor your response. Quality varies between brands - choose reputable manufacturers only.
NR or NMN Dosage & Timing Recommendations
Recommended Dosage
NR: 150-1000mg daily (up to 1000mg established as safe upper limit); NMN: 250-1000mg daily (up to 1200mg shown safe in studies)
Optimal Timing
Can be taken with or without food; some evidence suggests NMN afternoon dosing may be beneficial for muscle responsiveness
Important Dosage Notes
Always start with the lowest effective dose and gradually increase as needed. Individual responses vary significantly based on body weight, metabolism, and health status.
NR or NMN Benefits & Effects
- ✓May improve insulin sensitivity
- ✓Potential cardiovascular benefits
- ✓May enhance mitochondrial function
- ✓Could support DNA repair mechanisms
- ✓May improve muscle function and exercise performance
- ✓Potential neuroprotective effects
- ✓May help with sleep quality and fatigue
- ✓Could support healthy aging processes
NR or NMN Side Effects & Safety Considerations
While NR or NMN is generally considered safe with a safety score of 8/10, some individuals may experience the following side effects:
- ⚠Generally well tolerated with minimal side effects
- ⚠Mild gastrointestinal upset
- ⚠Nausea (rare)
- ⚠Skin rash (rare with NR)
- ⚠Flushing (rare with NR)
- ⚠Leg cramps (rare)
NR or NMN Drug Interactions & Contraindications
NR or NMN may interact with certain medications or conditions. Consult your healthcare provider if you are taking:
- ⚡No major drug interactions reported
- ⚡Caution advised when combining with other longevity supplements
- ⚡May interact with diabetes medications due to insulin sensitivity effects
- ⚡Exercise caution with blood pressure medications
NR or NMN Reviews from Verified Biohackers
Biohacker, Entrepreneur, Author, Founder of Bulletproof
1000mg
Morning
9/10
“Essential for cellular energy and longevity pathways”
Biohacking Entrepreneur & Anti-Aging Pioneer
500mg NMN or 450mg NR
Morning
8/10
“NAD+ precursors for cellular energy and DNA repair”
Physician, Author, and Functional Medicine Expert
900mg
Daily
8/10
“NAD+ precursor for longevity, energy production, and cellular health”
Lawyer & Longevity Expert
Unknown
Unknown
8/10
“For cellular energy and aging pathways”
Longevity Biohacker and Former Network Security Professional
300mg
On waking
8/10
“NAD+ precursor for energy boost”
Longevity researcher and biohacker
Varies
Morning
7/10
“Focus on CD38 inhibition rather than supplementation”
Frequently Asked Questions About NR or NMN
What is NR or NMN?
Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are precursors to NAD+ (nicotinamide adenine dinucleotide), a crucial coenzyme involved in cellular energy metabolism, DNA repair, and aging processes. Both compounds aim to boost declining NAD+ levels associated with aging.
Is NR or NMN safe?
NR or NMN has a safety score of 8/10 based on available research and user reports.As with any supplement, individual responses may vary. Always start with the lowest effective dose and monitor for any adverse reactions.
How effective is NR or NMN?
NR or NMN has an effectiveness score of 65% with moderate evidence supporting its use. Effectiveness can vary significantly between individuals based on genetics, lifestyle, and health status.
Can I take NR or NMN with other supplements?
NR or NMN may interact with certain medications and supplements. Known interactions include: No major drug interactions reported, Caution advised when combining with other longevity supplements, May interact with diabetes medications due to insulin sensitivity effects, Exercise caution with blood pressure medications. Consult with a healthcare provider before combining supplements.