Rapamycin Supplement Guide: Benefits, Dosage & Reviews
Primary use is to extend lifespan and healthspan by inhibiting mTOR pathway and promoting autophagy.
Rapamycin (sirolimus) is a macrolide compound originally discovered from soil bacteria on Easter Island that inhibits the mTOR pathway. It is considered the gold standard of anti-aging drugs, showing consistent lifespan extension of 15-30% in animal studies and potential benefits for healthspan and multiple age-related conditions.
Rapamycin Key Metrics & Safety Profile
Research Quality & Regulatory Status
FDA & Regulatory Status
FDA approved for organ transplant rejection prevention and lymphangioleiomyomatosis treatment. Off-label use for longevity is not FDA approved.
Where to Buy Rapamycin
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💡 Pro Tip: Start with the lowest effective dose and monitor your response. Quality varies between brands - choose reputable manufacturers only.
Rapamycin Dosage & Timing Recommendations
Recommended Dosage
2-10mg weekly (commonly 5-6mg once weekly for longevity applications)
Optimal Timing
Once weekly on empty stomach, consistent timing preferred
Important Dosage Notes
Always start with the lowest effective dose and gradually increase as needed. Individual responses vary significantly based on body weight, metabolism, and health status.
Rapamycin Benefits & Effects
- ✓Lifespan extension (15-30% in animal studies)
- ✓Improved cardiac function
- ✓Enhanced cognitive function
- ✓Cancer prevention
- ✓Reduced cellular senescence
- ✓Improved immune function
- ✓Skin anti-aging benefits
- ✓Hair repigmentation
- ✓Potential fertility preservation
- ✓Reduced visceral fat
- ✓Blood stem cell protection
Rapamycin Side Effects & Safety Considerations
While Rapamycin is generally considered safe with a safety score of 6/10, some individuals may experience the following side effects:
- ⚠Mouth ulcers
- ⚠Delayed wound healing
- ⚠Increased infection risk
- ⚠Hyperglycemia/diabetes
- ⚠Hyperlipidemia
- ⚠Hypercholesterolemia
- ⚠Metallic taste in mouth
- ⚠Gastrointestinal issues
- ⚠Potential lung toxicity
- ⚠Kidney dysfunction at high doses
Rapamycin Drug Interactions & Contraindications
Rapamycin may interact with certain medications or conditions. Consult your healthcare provider if you are taking:
- ⚡CYP3A4 inhibitors (ketoconazole, clarithromycin)
- ⚡CYP3A4 inducers (rifampin, carbamazepine)
- ⚡Grapefruit juice
- ⚡Immunosuppressants (cyclosporine, tacrolimus)
- ⚡ACE inhibitors
- ⚡Calcium channel blockers
- ⚡Live vaccines
- ⚡St. John's Wort
Rapamycin Reviews from Verified Biohackers
Longevity Biohacker and Former Network Security Professional
5-6mg
Every two weeks on Friday night
9/10
“mTOR inhibitor for autophagy enhancement”
Frequently Asked Questions About Rapamycin
What is Rapamycin?
Rapamycin (sirolimus) is a macrolide compound originally discovered from soil bacteria on Easter Island that inhibits the mTOR pathway. It is considered the gold standard of anti-aging drugs, showing consistent lifespan extension of 15-30% in animal studies and potential benefits for healthspan and multiple age-related conditions.
Is Rapamycin safe?
Rapamycin has a safety score of 6/10 based on available research and user reports. This supplement is FDA approved.As with any supplement, individual responses may vary. Always start with the lowest effective dose and monitor for any adverse reactions.
How effective is Rapamycin?
Rapamycin has an effectiveness score of 85% with strong evidence supporting its use. Effectiveness can vary significantly between individuals based on genetics, lifestyle, and health status.
Can I take Rapamycin with other supplements?
Rapamycin may interact with certain medications and supplements. Known interactions include: CYP3A4 inhibitors (ketoconazole, clarithromycin), CYP3A4 inducers (rifampin, carbamazepine), Grapefruit juice, Immunosuppressants (cyclosporine, tacrolimus), ACE inhibitors, Calcium channel blockers, Live vaccines, St. John's Wort. Consult with a healthcare provider before combining supplements.