NAC Supplement Guide: Benefits, Dosage & Reviews
Serves as a glutathione precursor and direct antioxidant to support cellular protection, respiratory health, and detoxification processes.
N-Acetylcysteine (NAC) is a pharmaceutical-grade amino acid supplement that serves as a precursor to glutathione, the body's most important intracellular antioxidant. It has FDA approval for acetaminophen overdose treatment and is widely used for respiratory conditions, liver support, and cellular protection against oxidative stress.
NAC Key Metrics & Safety Profile
Research Quality & Regulatory Status
FDA & Regulatory Status
FDA approved for acetaminophen overdose and as mucolytic agent. Currently being reconsidered for dietary supplement classification due to prior drug approval status.
Where to Buy NAC
Compare prices from trusted brands.
💡 Pro Tip: Start with the lowest effective dose and monitor your response. Quality varies between brands - choose reputable manufacturers only.
NAC Dosage & Timing Recommendations
Recommended Dosage
600-1800mg daily
Optimal Timing
Empty stomach or with meals
Important Dosage Notes
Always start with the lowest effective dose and gradually increase as needed. Individual responses vary significantly based on body weight, metabolism, and health status.
NAC Benefits & Effects
- ✓Increases glutathione production
- ✓Supports respiratory health and reduces mucus
- ✓Protects liver from toxins
- ✓Reduces oxidative stress and inflammation
- ✓Supports immune function
- ✓May improve mental health symptoms
- ✓Helps with substance use disorders
- ✓Supports fertility in both sexes
- ✓May reduce COPD exacerbations
- ✓Supports cardiovascular health
NAC Side Effects & Safety Considerations
While NAC is generally considered safe with a safety score of 8/10, some individuals may experience the following side effects:
- ⚠Nausea and vomiting
- ⚠Gastrointestinal discomfort
- ⚠Diarrhea
- ⚠Rash and skin reactions
- ⚠Bad taste/odor
- ⚠Headache
- ⚠Fatigue
- ⚠Anaphylactoid reactions (rare, IV form)
NAC Drug Interactions & Contraindications
NAC may interact with certain medications or conditions. Consult your healthcare provider if you are taking:
- ⚡May reduce effectiveness of tetracycline antibiotics
- ⚡Can enhance effects of nitroglycerin
- ⚡May interact with activated charcoal
- ⚡Can affect blood clotting medications
- ⚡May interact with immunosuppressants
NAC Reviews from Verified Biohackers
Biohacking Entrepreneur & Anti-Aging Pioneer
1800 mg
With dinner
8/10
“Antioxidant and liver support”
Frequently Asked Questions About NAC
What is NAC?
N-Acetylcysteine (NAC) is a pharmaceutical-grade amino acid supplement that serves as a precursor to glutathione, the body's most important intracellular antioxidant. It has FDA approval for acetaminophen overdose treatment and is widely used for respiratory conditions, liver support, and cellular protection against oxidative stress.
Is NAC safe?
NAC has a safety score of 8/10 based on available research and user reports. This supplement is FDA approved.As with any supplement, individual responses may vary. Always start with the lowest effective dose and monitor for any adverse reactions.
How effective is NAC?
NAC has an effectiveness score of 85% with strong evidence supporting its use. Effectiveness can vary significantly between individuals based on genetics, lifestyle, and health status.
Can I take NAC with other supplements?
NAC may interact with certain medications and supplements. Known interactions include: May reduce effectiveness of tetracycline antibiotics, Can enhance effects of nitroglycerin, May interact with activated charcoal, Can affect blood clotting medications, May interact with immunosuppressants. Consult with a healthcare provider before combining supplements.