PQQ Supplement Guide: Benefits, Dosage & Reviews
Primary purpose is to support mitochondrial biogenesis, cellular energy metabolism, and provide neuroprotective benefits through enhanced ATP production and antioxidant activity
Pyrroloquinoline quinone (PQQ) is a redox cofactor that acts as a potent antioxidant and mitochondrial biogenesis enhancer. Originally identified as a cofactor in bacterial dehydrogenases, PQQ supports cellular energy metabolism, mitochondrial function, and has demonstrated neuroprotective properties in various experimental models.
PQQ Key Metrics & Safety Profile
Research Quality & Regulatory Status
FDA & Regulatory Status
FDA issued no objection letters for PQQ disodium salt as GRAS for use in specified beverages at levels up to 8-20 mg per serving
Where to Buy PQQ
Compare prices from trusted brands.
💡 Pro Tip: Start with the lowest effective dose and monitor your response. Quality varies between brands - choose reputable manufacturers only.
PQQ Dosage & Timing Recommendations
Recommended Dosage
20 mg daily
Optimal Timing
With breakfast
Important Dosage Notes
Always start with the lowest effective dose and gradually increase as needed. Individual responses vary significantly based on body weight, metabolism, and health status.
PQQ Benefits & Effects
- ✓Promotes mitochondrial biogenesis
- ✓Enhances ATP production and cellular energy metabolism
- ✓Provides potent antioxidant protection
- ✓Supports cognitive function and memory
- ✓Improves sleep quality and mood
- ✓Reduces inflammation markers
- ✓Neuroprotective effects in neurodegenerative conditions
- ✓Supports cardiovascular health
- ✓May improve insulin sensitivity
PQQ Side Effects & Safety Considerations
While PQQ is generally considered safe with a safety score of 8/10, some individuals may experience the following side effects:
- ⚠Generally well tolerated with minimal reported side effects
- ⚠Potential kidney effects at very high doses
- ⚠Gastrointestinal upset in sensitive individuals
PQQ Drug Interactions & Contraindications
PQQ may interact with certain medications or conditions. Consult your healthcare provider if you are taking:
- ⚡Limited interaction data available
- ⚡Consult healthcare provider before combining with medications
- ⚡May enhance effects of other antioxidants
PQQ Reviews from Verified Biohackers
Biohacker, Entrepreneur, Author, Founder of Bulletproof
20mg daily
Morning
9/10
“Supports mitochondrial biogenesis and brain health”
Frequently Asked Questions About PQQ
What is PQQ?
Pyrroloquinoline quinone (PQQ) is a redox cofactor that acts as a potent antioxidant and mitochondrial biogenesis enhancer. Originally identified as a cofactor in bacterial dehydrogenases, PQQ supports cellular energy metabolism, mitochondrial function, and has demonstrated neuroprotective properties in various experimental models.
Is PQQ safe?
PQQ has a safety score of 8/10 based on available research and user reports.As with any supplement, individual responses may vary. Always start with the lowest effective dose and monitor for any adverse reactions.
How effective is PQQ?
PQQ has an effectiveness score of 72% with moderate evidence supporting its use. Effectiveness can vary significantly between individuals based on genetics, lifestyle, and health status.
Can I take PQQ with other supplements?
PQQ may interact with certain medications and supplements. Known interactions include: Limited interaction data available, Consult healthcare provider before combining with medications, May enhance effects of other antioxidants. Consult with a healthcare provider before combining supplements.