Alpha-GPC Supplement Guide: Benefits, Dosage & Reviews
Primary purpose is cognitive enhancement and support of cholinergic neurotransmission for memory, learning, and attention.
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a choline-containing phospholipid that serves as a precursor to acetylcholine, a key neurotransmitter involved in memory, learning, and attention. It crosses the blood-brain barrier effectively and supports both cognitive function and cellular membrane health.
Alpha-GPC Key Metrics & Safety Profile
Research Quality & Regulatory Status
FDA & Regulatory Status
Available as dietary supplement in US, prescription medication in Europe for Alzheimer's disease. NOAEL established at 150mg/kg body weight per day.
Where to Buy Alpha-GPC
Compare prices from trusted brands.
💡 Pro Tip: Start with the lowest effective dose and monitor your response. Quality varies between brands - choose reputable manufacturers only.
Alpha-GPC Dosage & Timing Recommendations
Recommended Dosage
300-1200mg daily, typically divided into 2-3 doses
Optimal Timing
With or without food, divided doses throughout the day to maintain stable blood levels
Important Dosage Notes
Always start with the lowest effective dose and gradually increase as needed. Individual responses vary significantly based on body weight, metabolism, and health status.
Alpha-GPC Benefits & Effects
- ✓Enhanced memory and learning
- ✓Improved attention and focus
- ✓Increased motivation
- ✓Support for cognitive decline in dementia/Alzheimer's
- ✓Neuroprotective effects
- ✓Enhanced power output in athletes
- ✓Growth hormone support
- ✓Cellular membrane support
Alpha-GPC Side Effects & Safety Considerations
While Alpha-GPC is generally considered safe with a safety score of 8/10, some individuals may experience the following side effects:
- ⚠Heartburn
- ⚠Headache
- ⚠Nausea
- ⚠Insomnia
- ⚠Dizziness
- ⚠Skin rash
- ⚠Confusion
- ⚠Gastrointestinal upset
Alpha-GPC Drug Interactions & Contraindications
Alpha-GPC may interact with certain medications or conditions. Consult your healthcare provider if you are taking:
- ⚡May enhance effects of acetylcholinesterase inhibitors
- ⚡May interact with anticholinergic drugs
- ⚡May potentiate scopolamine effects
- ⚡Potential interactions with cholinergic medications
Alpha-GPC Reviews from Verified Biohackers
Neuroscientist and Professor at Stanford University School of Medicine
300-600mg
30-60 minutes before workouts, 3-5x per week
8/10
“Enhances focus and cognitive performance for training”
Frequently Asked Questions About Alpha-GPC
What is Alpha-GPC?
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a choline-containing phospholipid that serves as a precursor to acetylcholine, a key neurotransmitter involved in memory, learning, and attention. It crosses the blood-brain barrier effectively and supports both cognitive function and cellular membrane health.
Is Alpha-GPC safe?
Alpha-GPC has a safety score of 8/10 based on available research and user reports.As with any supplement, individual responses may vary. Always start with the lowest effective dose and monitor for any adverse reactions.
How effective is Alpha-GPC?
Alpha-GPC has an effectiveness score of 75% with moderate evidence supporting its use. Effectiveness can vary significantly between individuals based on genetics, lifestyle, and health status.
Can I take Alpha-GPC with other supplements?
Alpha-GPC may interact with certain medications and supplements. Known interactions include: May enhance effects of acetylcholinesterase inhibitors, May interact with anticholinergic drugs, May potentiate scopolamine effects, Potential interactions with cholinergic medications. Consult with a healthcare provider before combining supplements.