Sulforaphane Supplement Guide: Benefits, Dosage & Reviews
Supports cellular detoxification, antioxidant defense, and longevity through Nrf2 pathway activation.
Sulforaphane is a powerful isothiocyanate compound derived from cruciferous vegetables like broccoli and cabbage. It acts as a potent Nrf2 activator, regulating over 200 genes involved in cellular defense, detoxification, and longevity pathways.
Sulforaphane Key Metrics & Safety Profile
Research Quality & Regulatory Status
FDA & Regulatory Status
Generally recognized as safe in food amounts, but no FDA approval for therapeutic use
Where to Buy Sulforaphane
Compare prices from trusted brands.
💡 Pro Tip: Start with the lowest effective dose and monitor your response. Quality varies between brands - choose reputable manufacturers only.
Sulforaphane Dosage & Timing Recommendations
Recommended Dosage
10-40mg daily
Optimal Timing
With food to minimize digestive upset
Important Dosage Notes
Always start with the lowest effective dose and gradually increase as needed. Individual responses vary significantly based on body weight, metabolism, and health status.
Sulforaphane Benefits & Effects
- ✓Activates Nrf2 pathway regulating 200+ genes
- ✓Enhances cellular detoxification (Phase I and II enzymes)
- ✓Increases glutathione production
- ✓Reduces inflammation and oxidative stress
- ✓Supports cardiovascular health
- ✓May promote longevity and healthy aging
- ✓Supports brain health and cognitive function
- ✓May help with weight management
- ✓Antimicrobial effects against H. pylori
- ✓Supports liver health and function
Sulforaphane Side Effects & Safety Considerations
While Sulforaphane is generally considered safe with a safety score of 8/10, some individuals may experience the following side effects:
- ⚠Heartburn
- ⚠Upset stomach
- ⚠Mild digestive issues
- ⚠Potential detox reactions (Herxheimer effect)
Sulforaphane Drug Interactions & Contraindications
Sulforaphane may interact with certain medications or conditions. Consult your healthcare provider if you are taking:
- ⚡CYP1A2 substrate medications
- ⚡Liver-metabolized drugs (CYP450 enzymes)
- ⚡Blood glucose-lowering medications
- ⚡Furosemide, verapamil, ketoprofen
- ⚡May affect thyroid function in iodine-deficient individuals
Sulforaphane Reviews from Verified Biohackers
PhD in Biomedical Science, Health Optimization Expert
2 tablets
With breakfast
9/10
“Activates Nrf2 pathway for detoxification”
Frequently Asked Questions About Sulforaphane
What is Sulforaphane?
Sulforaphane is a powerful isothiocyanate compound derived from cruciferous vegetables like broccoli and cabbage. It acts as a potent Nrf2 activator, regulating over 200 genes involved in cellular defense, detoxification, and longevity pathways.
Is Sulforaphane safe?
Sulforaphane has a safety score of 8/10 based on available research and user reports.As with any supplement, individual responses may vary. Always start with the lowest effective dose and monitor for any adverse reactions.
How effective is Sulforaphane?
Sulforaphane has an effectiveness score of 75% with strong evidence supporting its use. Effectiveness can vary significantly between individuals based on genetics, lifestyle, and health status.
Can I take Sulforaphane with other supplements?
Sulforaphane may interact with certain medications and supplements. Known interactions include: CYP1A2 substrate medications, Liver-metabolized drugs (CYP450 enzymes), Blood glucose-lowering medications, Furosemide, verapamil, ketoprofen, May affect thyroid function in iodine-deficient individuals. Consult with a healthcare provider before combining supplements.