Metformin ER Supplement Guide: Benefits, Dosage & Reviews
Controls blood sugar levels in adults and children 10+ years with type 2 diabetes mellitus as an adjunct to diet and exercise
Metformin ER is an extended-release formulation of metformin hydrochloride, a biguanide antihyperglycemic medication used to manage type 2 diabetes. It provides 24-hour blood sugar control with once-daily dosing and has fewer gastrointestinal side effects compared to immediate-release formulations.
Metformin ER Key Metrics & Safety Profile
Research Quality & Regulatory Status
FDA & Regulatory Status
FDA approved for type 2 diabetes treatment. Black box warning for lactic acidosis. Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²)
Where to Buy Metformin ER
Compare prices from trusted brands.
💡 Pro Tip: Start with the lowest effective dose and monitor your response. Quality varies between brands - choose reputable manufacturers only.
Metformin ER Dosage & Timing Recommendations
Recommended Dosage
500-2000mg once daily with evening meal
Optimal Timing
With evening meal
Important Dosage Notes
Always start with the lowest effective dose and gradually increase as needed. Individual responses vary significantly based on body weight, metabolism, and health status.
Metformin ER Benefits & Effects
- ✓24-hour glucose control with once-daily dosing
- ✓Reduces hepatic glucose production
- ✓Improves insulin sensitivity
- ✓Decreases intestinal glucose absorption
- ✓Lower risk of gastrointestinal side effects vs immediate-release
- ✓Does not typically cause hypoglycemia when used alone
- ✓May promote modest weight loss
- ✓Cardiovascular protective effects
Metformin ER Side Effects & Safety Considerations
While Metformin ER is generally considered safe with a safety score of 8/10, some individuals may experience the following side effects:
- ⚠Diarrhea
- ⚠Nausea and vomiting
- ⚠Flatulence
- ⚠Abdominal discomfort
- ⚠Metallic taste
- ⚠Headache
- ⚠Lactic acidosis (rare but serious)
- ⚠Vitamin B12 deficiency with long-term use
Metformin ER Drug Interactions & Contraindications
Metformin ER may interact with certain medications or conditions. Consult your healthcare provider if you are taking:
- ⚡Alcohol - increases lactic acidosis risk
- ⚡Carbonic anhydrase inhibitors (topiramate, acetazolamide)
- ⚡Cimetidine - increases metformin levels
- ⚡Ranolazine, vandetanib, dolutegravir
- ⚡Insulin and sulfonylureas - increased hypoglycemia risk
- ⚡Iodinated contrast agents
- ⚡Diuretics, corticosteroids, phenothiazines
Metformin ER Reviews from Verified Biohackers
Biohacking Entrepreneur & Anti-Aging Pioneer
1000 mg morning, 500 mg dinner
With meals
9/10
“For longevity and metabolic health”
Professor of Genetics at Harvard Medical School and Longevity Researcher
800-1000mg
Evening
8/10
“Prescription drug for glucose regulation and mTOR inhibition”
Frequently Asked Questions About Metformin ER
What is Metformin ER?
Metformin ER is an extended-release formulation of metformin hydrochloride, a biguanide antihyperglycemic medication used to manage type 2 diabetes. It provides 24-hour blood sugar control with once-daily dosing and has fewer gastrointestinal side effects compared to immediate-release formulations.
Is Metformin ER safe?
Metformin ER has a safety score of 8/10 based on available research and user reports. This supplement is FDA approved.As with any supplement, individual responses may vary. Always start with the lowest effective dose and monitor for any adverse reactions.
How effective is Metformin ER?
Metformin ER has an effectiveness score of 85% with strong evidence supporting its use. Effectiveness can vary significantly between individuals based on genetics, lifestyle, and health status.
Can I take Metformin ER with other supplements?
Metformin ER may interact with certain medications and supplements. Known interactions include: Alcohol - increases lactic acidosis risk, Carbonic anhydrase inhibitors (topiramate, acetazolamide), Cimetidine - increases metformin levels, Ranolazine, vandetanib, dolutegravir, Insulin and sulfonylureas - increased hypoglycemia risk, Iodinated contrast agents, Diuretics, corticosteroids, phenothiazines. Consult with a healthcare provider before combining supplements.